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Brain and Spinal Cord Atrophy
Program Overview
Target Audience
Educational Objectives
Disclaimer
CME Information
Credit Designation
Date of Release and Expiration
Statement of Responsibility
Privacy Statement Copyright 2004, The Johns Hopkins University School of Medicine. All rights reserved.
Faculty Dr. Calabresi is an associate professor of neurology and director of The Johns Hopkins Multiple Sclerosis (MS) Center. He specializes in the diagnosis and management of MS. As director of the MS clinic, Dr. Calabresi is the principal investigator on several clinical trials and also oversees translational laboratory research projects. Dr. Calabresi has designed and directed several clinical trials investigating combination drug therapies in MS. He is on the advisory board for 3 national multicenter clinical trials. Dr. Calabresi's specific laboratory research interest lies in understanding the mechanisms of T lymphocyte migration into the brain and spinal cord. He has published numerous articles on the adhesion molecules and chemokine receptors responsible for T cell homing to the brain in MS. He recently reported on a novel potassium channel, Kv1.3, which is specifically and highly expressed on chronically activated immune cells in the blood and brains of people with MS. The availability of Kv1.3 blocking drugs makes this an attractive future therapeutic target in MS. Dr. Calabresi was also recently awarded a 5-year collaborative MS center grant from the National Multiple Sclerosis Society to study mechanisms of neurodegeneration and strategies for neuroprotection in MS.
Rohit Bakshi, MD Rohit Bakshi, MD, FAAN, is an associate professor of neurology at Harvard Medical School, neurologist and neuroimager at Brigham and Women's Hospital, director of clinical MRI/MS imaging at the Partners Multiple Sclerosis Center, and researcher at the Center for Neurological Imaging. A Buffalo native and graduate of Cornell University, he received his MD from the SUNY University at Buffalo. As an Alpha Omega Alpha scholar, he completed a one-year neuroscience research fellowship with Dr. Alan Faden at the University of California, San Francisco. He served a one-year internship at the Massachusetts General Hospital and Harvard Medical School followed by a neurology residency at UCLA, where he performed neuroimaging research with Dr. John Mazziotta. He then completed a one-year MRI/CT neuroimaging fellowship at the Dent Neurologic Institute followed by continuing training in functional imaging and brain mapping, including PET and SPECT. Dr. Bakshi is board-certified in neurology and certified in MRI-CT by the American Society of Neuroimaging. He previously served on the faculty at the University at Buffalo-SUNY, where he rose to the rank of Associate Professor of Neurology with Tenure and was Residency Program Director. He was the founding director of the Buffalo Neuroimaging Analysis Center (BNAC), neurologist and neuroimager, and multiple sclerosis specialist at the Dent Neurologic Institute, the Jacobs Neurological Institute, and Physicians Imaging Centers. In building his research program at the BNAC, he pursued studies of quantitative MRI in MS, funded by the National Institutes of Health, National Science Foundation, and National MS Society. He received the 1998 William H. Oldendorf Award for neuroimaging research. He is a member of the American Neurological Association, has achieved fellow status in the American Academy of Neurology, and is a grant reviewer for NIH. He serves on the editorial board of The Journal of Neuroimaging and as associate editor of NeuroRx. He is the president of the American Society of Neuroimaging. He has delivered more than 100 invited lectures and has authored more than 300 publications, including print and online articles and abstracts, more than 110 of which are peer reviewed articles. His work has appeared in a variety of journals such as The New England Journal of Medicine, The Journal of Neuroscience, Neurology, NeuroImage, AJNR: American Journal of Neuroadiology, Annals of Neurology, The Journal of Computer Assisted Tomography, NeuroReport, Multiple Sclerosis, Archives of Neurology, Brain Research, The Journal of Neurology Neurosurgery and Psychiatry, and Medscape.
Robert Zivadinov, MD, PhD Robert Zivadinov, MD, PhD, is an associate professor of medicine at the University at Buffalo School of Medicine and Biomedical Sciences. He has staff privileges at The Jacobs Neurological Institute, Baird MS Research Center, Kaleida Health, Buffalo Neuroimaging Analysis Center and Physician Imaging Center. Dr. Zivadinov received his medical degree from the University of Rijeka in Croatia, and he obtained a master's in neurology at the University of Rijeka. He served a one-year internship at the department of neurology at the University of Trieste in Italy, followed by a neurology residency at the same institute from 1995 to 1999, where he performed neuroimaging research with Professor Marino Zorzon. Under the supervision of Professor Giuseppe Cazzato, he performed training in MS care at the Center for Diagnosis and Treatment of Multiple Sclerosis in the department of clinical medicine and neurology at the University of Trieste. In 1999 he became the chief researcher on MS in the same institute. In 1998 he founded the Postimaging Analysis Center at Center for Diagnosis and Treatment of Multiple Sclerosis, in the department of clinical medicine and neurology at University of Trieste; he covered the role of its executive director from 1998 to 2002. As a chief researcher, Dr. Zivadinov conducted and led significant and progressive research studies in the field of MS. Since 1999, he has also been an MS research consultant for several international pharmaceutical companies and foundations. Dr. Zivadinov has acquired extensive research experience in MS. His accomplishments in his field include: numerous awards from European and national neurological societies for his published articles, research studies and research fellowships. Dr. Zivadinov obtained his PhD in neurology at the University of Rijeka. In 2003, he was appointed to associate professor of neurology at the University at Buffalo School of Medicine and Biomedical Sciences and to director of the Buffalo Neuroimaging Analysis Center. He has authored more than 40 publications, including print and online articles and 85 abstracts. His work has appeared in journals such as Neurology; The Journal of Neurology, Neurosurgery and Psychiatry; Neuroimage; The Journal of Neurology; Multiple Sclerosis; and Neuroepidemiology. Dr. Zivadinov is currently pursuing research studies of quantitative MRI findings in MS, therapeutic interventions including strategies towards assessing neuroprotective efforts in MS, but his current interests are also concentrated on genetic and neuroepidemiology fields of the same disease.
Faculty Disclosures Dr. Rohit Bakshi has received grant and research support as well as honoraria from Biogen Idec, Teva Neuroscience, Inc. and Serono, Inc. Dr. Peter Calabresi has received grant and research support and served as a consultant with Biogen Idec, Berlex, Inc., Teva Neuroscience, Inc. and Serono, Inc. Dr. Robert Zivadinov has no affiliations, financial interests or other related relationships to disclose.
Off-Label Discussion
This educational program is supported through an educational grant from Biogen Idec.
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